Highlights
- Genetic background affects the outcome of adolescent cannabis exposure
- THC exposure increases heroin reinforcing properties in LEW addiction prone rats
- LEW, but not F344 rats, show increased motivation for heroin following THC
- THC exposure increases reinstatement by cues in F344 and by priming in LEW rats
- A common liability mechanism might be at the basis of THC gateway effect
https://www.sciencedirect.com/science/article/abs/pii/S002839082030040X (2020)