Adolescent Cannabis Exposure Increases Heroin Reinforcement In Rats Genetically Vulnerable To Addiction

Highlights

  • Genetic background affects the outcome of adolescent cannabis exposure
  • THC exposure increases heroin reinforcing properties in LEW addiction prone rats
  • LEW, but not F344 rats, show increased motivation for heroin following THC
  • THC exposure increases reinstatement by cues in F344 and by priming in LEW rats
  • A common liability mechanism might be at the basis of THC gateway effect

https://www.sciencedirect.com/science/article/abs/pii/S002839082030040X (2020)

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