Comments: There is currently no high-quality evidence supporting pharmacological treatment to control drinking in patients with alcohol use disorder. The risks of incomplete outcome data or selective outcome reporting were identified by this report. In addition, no study demonstrated a benefit on health outcomes. More evidence is needed on this topic.
Nicolas Bertholet, MD, MSc
Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders: a systematic review with direct and network metaanalyses on nalmefene, naltrexone, acamprosate, baclofen and topiramate. Addiction. 2018;113(2):220–237.